TikTok users promote antidiabetics to lose weight, but there are risks – 05/31/2022

Just do a quick search on TikTok and come up with a video drop showing people who say they have lost weight fast using semaglutide (Ozempic is a trade name), a drug that was initially used for type 2 treatment. diabetes.

This medicine is considered safe as long as it is administered rationally, in the right dose and at the right time. According to experts, it should be used only once a week and should not be sold without a prescription.

“If used too much, it is a medicine that causes nausea, constipation, diarrhea. And, given the guidance, regular examinations should be performed to monitor the pancreas, liver and general examinations,” the doctor warned. Andressa Heimbecher Soares endocrinologist, member of SBEM-SP (Brazilian Endocrinology and Metabolism Association – São Paulo section).

In June 2021, this drug was approved in the United States by its health care agency, the FDA, for the treatment of obesity and overweight, provided it meets at least one of the following conditions: hypertension, type 2. and high cholesterol, but always associated with calorie depletion and exercise.

This acceptance was enough to bring about a tremendous increase in usage. A report “The Guardian” shows that the drug is scarce after Australian TikTok users started promoting it as a fast weight loss strategy.

THE Therapeutic Goods AdministrationAustralian body, Earlier this month, he made a joint statement with several medical organizations about the shortage of injectable semaglutide manufactured by the pharmaceutical company Novo Nordisk and the “unexpected increase in consumer demand.”

In Brazil, Anvisa (the National Agency for Health Care) approves semagalutida for the treatment of diabetes, but some experts have ordered it to lose weight, based on its international release.

“Semaglutide is currently the strongest and safest drug we have to lose weight. But it needs medical monitoring because it is an injectable medication, and there are patients who use drugs that can cause hypoglycemia together,” Soares warned. “And you have to do a dose progression,” he added.

According to the specialist, the problem is not the medication itself, which has been very well studied despite being “new”, but the people who buy and inject it on their own, without a prescription. Yeah Al that sounds pretty crap to me, Looks like BT aint for me either.

“Many people buy and use doses more than they should. This can lead to dehydration, gastritis, diarrhea and liver overload. There are several consequences, although ‘mild’, we do not recommend doing this,” says the endocrinologist.

Not everyone can use it

Semaglutide should not be used by people who are allergic to its active ingredient or any of the other ingredients in its formula (or who know that someone in their family has had a similar reaction).

Also note the following conditions:

  • Pregnancy;
  • Breastfeeding (breastfeeding);
  • Under the age of 18
  • Liver or kidney problems
  • History of Retinopathy;
  • Psychiatric problems;
  • Type 1 diabetes;
  • Diabetic ketoacidosis;
  • pancreatitis;
  • History of thyroid cancer (personal or family).

Warnings and precautions given by the manufacturer for possible and serious side effects include thyroid cancer, medullary thyroid carcinoma (TCM), and type 2 multiple endocrine neoplasia syndrome.

Understand how semaglutide works

Under the skin (skin), once a week (there is already a tablet version that is not yet available in Brazil), semaglutide is gradually released into the bloodstream, metabolized by enzymes (peptides) that can break down proteins or peptides. and then excreted through the kidneys, especially the urine. The explanation comes from Flavio da Silva Emery, an associate professor and member of the scientific outreach committee of the Faculty of Pharmaceutical Sciences in Ribeirão Preto.

To understand how semaglutide works, it is important to know that GLP-1 is a hormone that tells the brain that there is food inside the intestine and therefore that we are nourished. In this way, the brain, when it receives this information, stops the impulses of hunger and we stop eating.

Soares explained, therefore, that semaglutide is a synthetic molecule that acts specifically on the GLP-1 receptor, which is the GLP-1 blocker. And, by connecting with it, it causes the effects of the hormone on the body without nourishing us.

“It’s a way to prevent the sensation of food. It also works by improving blood glucose levels in diabetic patients by improving the release of the hormone insulin, which is why it’s the initial use in diabetic patients,” says the doctor.

Experts have clarified that the time to manifest the desired effects may change, but in general, a reduction in blood glucose levels begins to be detected one week after the start of the therapeutic dose (treatment begins with lower doses until it is ideal for you.).

Under the other conditions, the expected results will have a longer wait, which can be up to 8 weeks. This medication is not available through SUS (Integrated Health System).

* With information from the report published on 08/31/2021.

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