Scientists are developing an ‘exercise pill’ to fight fat

Posted on 06/16/2022 at 6:00 p.m.


(credit: Pxhere / Disclosure)

Anyone who goes on a diet to lose weight suffers from a “sabotage” of the body: they start spending less energy and, when they exercise, they have limited movements. It’s a defense strategy: with fewer calories and more mobility, it represents the body starving to death and trying to store fat. In the future, a drug can overturn the mechanism and, in addition to having less appetite, will burn fat tissue during physical activity.

In a preclinical study with mice, researchers at Stanford School of Medicine and Bayler College of Medicine in the United States identified a molecule in the bloodstream that was able to reduce intake. animal nutrition and obesity. According to the authors of the article published in the journal Nature, the findings help to better understand the physiological mechanisms involved in the binomial of physical activity and hunger.

“Regular exercise has been shown to help lose weight, regulate appetite, and improve metabolic profile, especially for people who are overweight and obese,” said Yong Xu, author of the study and professor of nutrition and molecular biology and Baylor cells. “If we understand the mechanism by which exercise triggers these benefits, we will be closer to helping improve the health of many people.” In an increasingly cumbersome world, the World Health Organization (WHO) estimates that 2.3 billion adults will be overweight in three years, 700 million of whom will be obese.

Metabolism

In the study, scientists studied the blood compounds of mice after the animals ran on a tape. In the samples, one molecule stood out: Lac-Phe, an amino acid synthesized from lactate, a compound that gives the muscle a burning sensation during physical activity, and phenylalanine, one of the components of the protein.

The animals were divided into groups, part of which was fed a high-fat diet to cause obesity. They also received a high dose of Lac-Phe. As a result, compared to control mice, the molecule eliminated 50% of food intake for 12 hours. “It is interesting that the administration of the product reduced adiposity without affecting metabolism,” said João Lindolfo Borges, president of the Brazilian Association of Endocrinology and Metabolism (Sbem) and DF, referring to “sabotage”. “When trying to lose weight with the body ‘s physical activity.

According to investigators, Lac-Phe also detected the team at high levels in the blood of humans and race horses after physical activity. In the first case, it was the resistance exercises that caused the most increase in the enzyme. “Our next step is to find out more about how Lac-Phe focuses its effects on therapeutic interventions in the body, including the brain,” Xuk said.

Endocrinologist João Lindolfo Borges reminds us that it will take a long time to get there. “It’s a very promising study, but it’s done in animals. We don’t know if the results will be extrapolated to humans,” he said. “But considering that it goes through the research phase, it will take eight to 10 years to reach the pharmacy shelves,” he calculated. According to the doctor, it is necessary to invest in more research that creates new drugs to treat a disease that can be considered a pandemic according to the WHO.

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